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HIGHLY EFFICIENT SYNTHESIS OF 2-AMINO-3-PYRIDINECARBOXALDEHYDE
13
Citations
4
References
2001
Year
EngineeringSustainable SynthesisAcid HydrolysisOrganic ChemistryMajor ImpuritiesCatalysisChemistryHighly Efficient SynthesisHeterocycle ChemistrySynthesis MethodSynthetic ChemistryBiomolecular EngineeringEfficient Process
2-Amino-3-pyridinecarboxaldehyde is synthesized in a highly efficient process via ortho-lithiation of 2-(pivaloylamino)pyridine and reaction with DMF, followed by acid hydrolysis. Major impurities were identified and were cleanly eliminated through careful choice of base and solvent.
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