Publication | Closed Access
A Concise Synthesis of a Novel Antiangiogenic Tyrosine Kinase Inhibitor
55
Citations
6
References
2004
Year
Concise SynthesisMedicinal ChemistryNovel TherapyDicyclohexylamine-mediated Suzuki CouplingDrug DiscoveryMedicineReceptor Tyrosine KinaseNoncryogenic Indole BoronationEfficient SynthesisHeterocycle ChemistryAnti-cancer AgentPharmacologyPharmaceutical ChemistrySynthetic ChemistryBiomolecular Engineering
An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indole boronation and a dicyclohexylamine-mediated Suzuki coupling.
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