Endogenous opioids in cerebrospinal fluid of opioid-dependent humans

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Opiate Receptor: Demonstration in Nervous Tissue

Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations

Medicine, Neuroscience, Pharmacology +10

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

Eric J. Simon, Jacob M. Hiller, Irit Edelman · Proceedings of the National Academy of Sciences · 1973 · 1.1K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Characteristics of the “Receptor” for Narcotic Analgesics in Synaptic Plasma Membrane Fraction from Rat Brain

Lars Terenius · Acta Pharmacologica et Toxicologica · 1973 · 436 citations

Medicine, Neuroscience, Pharmacology +17

An endogenous morphine-like factor in mammalian brain

Gavril W. Pasternak, Robert Goodman, Solomon H. Snyder · Life Sciences · 1975 · 393 citations

Life Sciences, Neurobiology, Neuroscience +14