Screening for neural tube defect: false positive findings on ultrasound and in amniotic fluid.

Abstract

CommentsThe study shows that high doses of 5-amino salicylic acid and sulphasalazine were equally effective in maintaining remission in patients with ulcerative colitis, but the increased dose appeared to have no real advantage over the lower dose of 12 g previously used.Higher serum concentrations of 5-amino salicylic acid and acetyl 5-amino salicylic acid were recorded in the serum of patients taking the oral 5-amino salicylic acid preparation compared with those taking sulphasalazine.It is possible that the higher doses might be of value in treating acute colitis.We thank Boots Pure Drug Company, Nottingham for supplying placebo sulphasalazine, and Rohm Pharma GMB for preparing the tablets of 5-amino salicylic acid.Inquiries about 5-amino salicylic acid should be sent to Tillotts Laboratory, Henlow, Bedfordshire.