Infective Pneumoconiosis: 1. The Influence of Dead Tubercle Bacilli (B.C.G.) on the Dust Lesions Produced by Anthracite, Coal-mine Dust, and Kaolin in the Lungs of Rats and Guinea-pigs

Abstract

The close association between silicosis and tuber- cular infection has long been recognized. In South Africa, Mavrogordato (1926) and Strachan and Policard (1933) was of the opinion that practically all cases of silicosis were complicated by tuberculosis. Kettle and Archer (1933) observed that infective silicosis was more common in Great Britain than simple silicosis. By infective silicosis was meant " the modification in a dusty lung of the reaction of a chronic low-grade infection, frequently tuber- culosis, in the direction of increased fibrosis ", a definition first used by