Immunology and Cell Biology · 1968 · 24 citations · 0 references
MedicinePharmacologyExperimental PharmacologyNeuropharmacologyPharmacodynamicsAutonomic Nervous System PharmacologyAutonomic PharmacologyCardiovascular Drug InteractionsCardiovascular PharmacodynamicsCardiovascular PharmacologySerotonergic PharmacologyDrug PotentiationHemodynamic Drug EffectsNoradrenergic NeurotransmissionPharmacodynamics Of Cardiovascular DrugsPharmacology Of Serotonergic AgentsSerotonin AgonistsSerotonin PharmacodynamicsSympathetic Vasomotor Control
Summary The constrictor action of noradrenaline on the hand vessels was significantly enhanced in the presence of threshold amounts of angiotensin as was that of angiotensin in the presence of threshold amounts of serotonin. No such potentiation was seen with the same combinations in the forearm. In the forearm significant potentiation was only seen with constrictor doses of noradrenaline in the presence of threshold amounts of serotonin. No potentiation was seen with this combination in the hand vessels. Although statistically significant potentiation was seen with all three possible combinations of the drugs, it was not common to both vascular beds studied. Furthermore, it was often of a minor degree and inconsistent within the one combination. These considerations make it unlikely that these interactions are of biological importance in man.