Concepedia

Endothelin-1 Inhibits Endothelin-Converting Enzyme-1 Expression in Cultured Rat Pulmonary Endothelial Cells

Shojiro Naomi, Taisuke Iwaoka, Tumba G. Disashi, Junnosuke Inoue, Yoshie Kanesaka, Hiroshi Tokunaga, Kimio Tomita

Circulation · 1998 · 47 citations · 10 references

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Abstract

The present results demonstrate that ET-1 suppressed ECE-1 protein levels by inhibiting ECE-1 mRNA expression through the ETB receptor, suggesting the existence of a feedback action of ET-1 on ECE-1 in pulmonary endothelial cells.

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10

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