Palladium-Catalyzed Annulation of Arynes by<i>o</i>-Halobenzamides: Synthesis of Phenanthridinones

Abstract

The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.