Microwave-Enhanced Synthesis of N-Shifted Buflavine Analogues via a Suzuki−Ring-Closing Metathesis Protocol

Abstract

[reaction: see text] A novel, microwave-enhanced six-step synthesis was devised for the synthesis of N-shifted buflavine analogues. Microwave-enhanced Suzuki-Miyaura cross-coupling and ring-closing metathesis reactions were used as the key steps. Microwave irradiation was found to enhance the ring-closing metathesis reaction to generate the otherwise difficultly obtainable medium-sized ring system of the target molecules.