LiOAc-Catalyzed Chemoselective Deprotection of Aryl Silyl Ethers under Mild Conditions

Abstract

An efficient and chemoselective deprotection protocol for aryl silyl ethers using LiOAc as a bifunctional Lewis acid-Lewis base catalyst was described. Acetates, epoxides, and aliphatic silyl ethers were preserved, whereas aryl TBS and TBDPS ethers can be differentiated.