Changes in Spontaneous Behavior in Rats Exposed to Experimental Disc Herniation are Blocked by Selective TNF-Alpha Inhibition

Abstract

The data of the study clearly indicate a role for tumor necrosis factor alpha in the studied behavior changes after experimental disc herniation in the rat. Clinical trials must be performed in order to assess if there may be a clinical use for tumor necrosis factor alpha inhibition in the treatment of sciatica due to disc herniation.