Fibroblasts Express RANKL and Support Osteoclastogenesis in a COX-2-Dependent Manner After Stimulation With Titanium Particles

Abstract

Fibroblasts respond directly to titanium particles and increase RANKL expression through a COX-2/PGE2/EP4/PKA signaling pathway. Thus, the synovial fibroblast is important mediator of osteolysis and target for therapeutic strategies.