The genetic background of the<i>curly tail</i>strain confers susceptibility to folate‐deficiency‐induced exencephaly

Abstract

Dietary folate deficiency can induce cranial NTDs in nonmutant mice with a permissive genetic background, a situation that likely parallels gene-nutrient interactions in human NTDs. Our findings suggest that inositol supplementation may ameliorate NTDs resulting from insufficient dietary folate.