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Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study

BiochemistryMedicineBioanalysisMass SpectrometryPharmacokinetic StudyMetabolomic ProfilingHuman PlasmaAnalytical ChemistryMajor MetabolitesLiquid ChromatographyClinical ChemistryMetabolomicsChromatographic AnalysisPharmacologyPharmacokineticsChromatographyDrug Analysis