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SECRETION OF “INHIBIN” BY RAT GRANULOSA CELLS IN VITRO1
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1978
Year
OocyteProtein SecretionFertilityGranulosa CellReproductive BiologyCellular PhysiologyPituitary GlandSecretory GranulesRat Granulosa CellsPublic HealthCell SignalingCell PhysiologyMolecular PhysiologyEndocrine MechanismGranulocyteMorphogenesisRat Pituitary CellsEndocrinologyCell BiologyPhysiologyReceptor BiologyCellular BiochemistryMedicineReproductive Hormone
Rat granulosa cells secrete a substance in vitro that acts directly upon cultured rat pituitary cells to preferentially suppress FSH production. It is inferred from these results that the granulosa cell is a source of ovarian "inhibin" and that the pituitary gonadotroph is a site of "inhibin" action.