Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

Abstract

A molecular model showing the yeast tubulin–paclitaxel and tubulin–docetaxel complexes in a mutated form of the protein that contains Asn at position 227 instead of His. The side chain of Asn 227 is able to form an H-bond with the carbonyl oxygen of the paclitaxel benzamide and the docetaxel carbamate groups.