Oncology · 2009 · 17 citations · 4 references
MedicineNephrologyOncologyRenal PathologyRenal PathophysiologyRenal PharmacotherapyGlomerular InjuryKidney CancerRenal Cell CarcinomaRenal DiseaseRenal IschemiaRenal Ischemic InjuryFocal Segmental Glomerulosclerosis TherapyGlomerular HistopathologyKidney Biopsy AssessmentKidney Biopsy FindingsProteinuria ReductionRenal Biopsy Findings
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion. Kidney biopsy revealed ischemic glomeruli and focal segmental glomerulosclerosis lesion. Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal. Clinicians should be aware to this complication.
4
Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
Gary R. Hudes, Michael A. Carducci, Piotr Tomczak et al. · New England Journal of Medicine · 2007 · 3.6K citations
Medicine, Oncology, Chemotherapy +10