Oxandrolone for Growth Promotion in Turner Syndrome

Abstract

Nine girls with XO gonadal dysgenesis have been treated for periods of four months to 34 months with oxandrolone. Growth rate increased twofold to eightfold over the entire period of treatment, with less osseous maturation than expected for either chronologic aging or statural age advance. Growth acceleration was greatest during the first year of treatment. Noticeable side effects were not sufficient to stop treatment and were limited to voice change and pubic hair growth.