Deactivation of glass capillary columns by silylation. Part 1: Principles and basic technique

Abstract

Abstract A deactivation procedure is described based on a published method using hexamethyldisilazane in the gas phase. In addition to unusually high inertia and thermostability, the method produces truly neutral columns which allow simultaneous analysis of moderately strong free acids and bases. The silylated columns show their full potential only with on‐column injection. Preliminary experimental directions are given; more elaborate directions will become available after extended optimization work.