<i>Endoplasmic reticulum</i>targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(<scp>iv</scp>) vitamin-B6 complex in visible light

Abstract

An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. [VO(HL)(acdppz)]Cl, having (acridinyl)dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400-700 nm) in HeLa and MCF-7 cancer cells (IC50 < 0.6 μM) while being non-toxic in the dark and to MCF-10A normal cells (IC50 > 40 μM).