Interactions of 5'-UTR Thymidylate Synthase Polymorphism with 677C→ T Methylene Tetrahydrofolate Reductase and 66A→ G Methyltetrahydrofolate Homocysteine Methyl-transferase Reductase Polymorphisms Determine Susceptibility to Coronary Artery Disease

Abstract

Dietary folate status and TYMS 5'-UTR 28bp tandem repeat polymorphism are important effect modifiers of CAD risk associated with genetic variants in remethylating genes.