Transforming Growth Factor-β<sub>1</sub> and Myofibroblasts: A Potential Pathway towards Renal Scarring in Human Glomerular Disease

Abstract

The results of this study suggest that TGF-beta(1) plays an important role in the pathogenesis of fibrosis developing in human kidney, during the evolution of glomerular disease. Interstitial myofibroblasts may contribute to interstitial fibrosis through the synthesis and release of both TGF-beta1 and collagen III.