Molecular mechanisms of interleukin‐4–induced up‐regulation of type I collagen gene expression in murine fibroblasts

Abstract

Our observations indicate that IL-4 has a profound effect on several factors that have been identified as playing major roles in the regulation of collagen synthesis and suggest that IL-4 increases the expression of type I collagen through a mechanism involving the activation of transcription factors that bind to and activate collagen promoter.