Defective Circulating CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>CD127<sup>low</sup> Regulatory T-cells in Patients with Chronic Heart Failure

Abstract

Our data are the first to demonstrate that frequencies of circulating Tregs in patients with CHF are reduced and their suppressive function compromised independently of the etiology. Defective Tregs may be an underlying mechanism of immune activation in CHF patients.