PubMed · 2001 · 97 citations · 0 references
MedicineNeurosciencePharmacologyBehavioral NeuroscienceNeuropharmacologyPsychopharmacologyAntidepressant PharmacologyAntidepressant PharmacotherapyAntidepressant TherapyDepression PharmacotherapyLocomotor ControlLocomotor PhysiologyAntidepressant EfficacyAntidepressant ResponseLocomotor Activity PatternsMechanisms Of Antidepressant ActionNmda Receptor AntagonismNmda Receptor AntagonistsNmda Receptor PharmacologyPharmacodynamic Mechanisms
The effects of zinc, the NMDA receptor inhibitor, were studied in the forced swimming (Porsolt's) test in mice. Zinc (ZnSO4) at a dose of 30 mg/kg (but not at a dose of 10 mg/kg), similarly to imipramine (30 mg/kg), reduced the immobility time in that test. Moreover, zinc at both doses reduced the locomotor activity. The obtained results indicate that zinc induces an antidepressant-like effect in the forced swimming test. Since zinc reduces the locomotor activity, this antidepressant-like effect is not related to the alteration of general activity.