Improving the Trapping of Superoxide Radical with a β‐Cyclodextrin– 5‐Diethoxyphosphoryl‐5‐methyl‐1‐pyrroline‐<i>N</i>‐oxide (DEPMPO) Conjugate

Abstract

Trapped spin trap: CD-DEPMPO, a cyclodextrin–DEPMPO conjugate spin trap, exhibits improved performances in superoxide detection. Using blood as a biological model system, the superoxide CD-DEPMPO adduct was still unambiguously detected after 70 min, whereas using DEPMPO the signal of the superoxide adduct was not detected. (DEPMPO=5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide.) Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.