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Differential impact of the CYP3A5*1 and CYP3A5*3 alleles on pre-dose concentrations of two tacrolimus formulations

DOI

51

Citations

0

References

2010

Year

Markus Wehland, Steffen Bauer, Susanne Brakemeier, Philip Burgwinkel, Petra Glander, Reinhold Kreutz, Christine Lorkowski, Torsten Slowinski, H. H. Neumayer, Klemens Budde
Pharmacogenetics and Genomics

Abstract

This study provides further evidence that the CYP3A5*1/*3 polymorphism significantly impacts Tac pharmacokinetics. Moreover, we show for the first time a pharmacogenetic effect on two different Tac formulations, as Tac trough levels of *3/*3 patients declined significantly after conversion to identical A-Tac doses.