Hepatic (Na+, K+)–Atpase: A Current View of Its Structure, Function and Localization in Rat Liver As Revealed by Studies With Monoclonal Antibodies

Abstract

Correspondence) concerning the topology of rat hepatocyte (Na+,K+)-ATPase (4-6). Apart from the fact that this enzyme (the so-called "sodium pump") is crucial for regulating cellular volume (7), differentiation and proliferation (8), the issue of its whereabouts in the plasma membrane is particularly relevant to the mechanism of bile acid and water transport from sinusoidal to canalicular spaces. Theories of these processes depend on where and to what extent the sodium pump is distributed in cell surfaces adjacent to either one or both of these spaces (4-6, 9, 10, Yousef I. et al., op cit., Correspondence and Blitzer, B. and Boyer. J., op cit.,