Concepedia

Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4‐hydroxynonenal to cartilage degradation

Barbara Morquette, Qin Shi, Patrick Lavigne, Pierre Ranger, Julio Fernandes, Mohamed Benderdour

Arthritis & Rheumatism · 2005 · 86 citations · 49 references

DOI

Abstract

The increased level of HNE in OA cartilage and the ability of HNE to induce transcriptional and posttranslational modifications of CII and MMP-13 suggest that this aldehyde could play a role in OA.

References

49

Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee

Roy D. Altman, E. Asch, D. Blöch et al. · Arthritis & Rheumatism · 1986 · 6.7K citations

Protein damage and degradation by oxygen radicals. I. general aspects.

Kelvin J.A. Davies · Journal of Biological Chemistry · 1987 · 1.6K citations · Full text

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

R. Clark Billinghurst, Leif Dahlberg, Mirela Ionescu et al. · Journal of Clinical Investigation · 1997 · 972 citations · Full text

, , +22

S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

Zezong Gu, Marcus Kaul, Boxu Yan et al. · Science · 2002 · 945 citations

, , +25

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

Peter G. Mitchell, Holly A. Magna, Lucy Reeves et al. · Journal of Clinical Investigation · 1996 · 941 citations · Full text

, , +18