Concepedia

The Effect of Podoplanin Inhibition on Lymphangiogenesis Under Pathological Conditions

Yuko Maruyama, Kazuichi Maruyama, Yukinari Kato, Kentaro Kajiya, Satoru Moritoh, Kotaro T. Yamamoto, Yuko Matsumoto, Mika Sawane, Dontscho Kerjaschki, Toru Nakazawa,

Investigative Ophthalmology & Visual Science · 2014 · 34 citations · 32 references

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Abstract

Podoplanin neutralization resulted in inhibition of lymphatic growth associated with corneal and ear wound healing as well as mps inflammation. These data suggest that podoplanin is a novel therapeutic target for suppressing lymphangiogenesis and inflammation.

References

32

Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries

Silvana Breiteneder-Geleff, Afschin Soleiman, Heinrich Kowalski et al. · American Journal Of Pathology · 1999 · 1.1K citations · Full text

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VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment

Claus Cursiefen, Lu Chen, Leonardo P. Borges et al. · Journal of Clinical Investigation · 2004 · 1K citations · Full text

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Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages

Kazuichi Maruyama, Masaaki Ii, Claus Cursiefen et al. · Journal of Clinical Investigation · 2005 · 713 citations · Full text

T1 /podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

Vivien Schacht · The EMBO Journal · 2003 · 664 citations · Full text

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Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing

Kazuichi Maruyama, Jun Asai, Masaaki Ii et al. · American Journal Of Pathology · 2007 · 486 citations · Full text

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