Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: Prevention by HDLs

Abstract

Oxidized LDLs (oxLDLs) induce various cellular dysfunctions potentially implicated in the pathogenesis ofatherosclerosis. For instance, toxic concentrations of oxLDLs trigger ER stress, autophagy and apoptosis. High-density lipoproteins (HDLs) counteract several adverse biological effects triggered by oxLDLs. Our recent study reveals that HDLs inhibit the activation of ER stress and of autophagy induced by oxLDLs.