Cytogenetics and Cell Genetics · 2008 · 24 citations · 0 references
Life SciencesGeneticsMolecular GeneticsComparative GenomicsGenomicsSequence AnalysisComparative Genomic HybridizationFish Comparative GenomicsFish GenomicsGene MappingSequence AlignmentSequence Similarity SearchComparative Genome OrganizationConserved Motif AlignmentConserved Motif DetectionMotif AlignmentSequence IdentitySequence Motif ConservationSequence Motif DiscoverySequence Motif Search
SOX genes share a high sequence identity with the HMG box present in the testis determining gene SRY. We have identified a HMG box-like sequence motif on six contiguous cosmids, which cross-hybridize to a SOX9 cDNA probe. A data base search revealed a high similarity of the deduced amino acid sequence to the human SOX12 and the murine Sox16 HMG domains. The cosmids were assigned to chromosome 17p13 by FISH analysis.