Concepedia

Development and qualification of a high sensitivity, high throughput Q-PCR assay for quantitation of residual host cell DNA in purification process intermediate and drug substance samples

Wei Zhang, Meng Wu, Emily Menesale, Tongjun Lu, Aeona Magliola, Svetlana Bergelson

Journal of Pharmaceutical and Biomedical Analysis · 2014 · 24 citations · 13 references

Concepts

MedicineMolecular BiologyMolecular GeneticsMolecular BiotechnologyMolecular DiagnosticsNucleic Acid BiochemistryAssay ValidationNucleic Acid Amplification TestingNucleic Acid ExtractionNucleic Acid PurificationPolymerase Chain ReactionDna ExtractionHigh-sensitivity AssaysHost Dna DepletionPolymerase Chain Reaction (Pcr) AssaysPurificationPurification Process DevelopmentQuantitative Polymerase Chain Reaction AssaysResidual Dna Quantification

References

13

L1 retrotransposition in human neural progenitor cells

Nicole G. Coufal, José L. García-Pérez, Grace E. Peng et al. · Nature · 2009 · 830 citations

Life Sciences, Genetics, Molecular Genetics +12

WHO Expert Committee on Biological Standardization.

Blanche Horowitz, P. Minor, Morgenthaler Jj et al. · PubMed · 1994 · 541 citations

Veterinary Medicine, Biotechnology, Immunology +17

Contribution of CpG motifs to the immunogenicity of DNA vaccines

Dennis M. Klinman, Galina V. Yamshchikov, Yoshiaki Ishigatsubo · The Journal of Immunology · 1997 · 512 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

A fundamental division in the Alu family of repeated sequences.

Jerzy Jurka, Tracey A. Smith · Proceedings of the National Academy of Sciences · 1988 · 391 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

The nucleotide sequence of the ubiquitous repetitive DNA sequence B1 complementary to the most abundant class of mouse fold-back RNA

A.S. Krayev, Dmitri A. Kramerov, K. G. Skryabin et al. · Nucleic Acids Research · 1980 · 328 citations · Full text

Life Sciences, Biology, Molecular Biology +8