SIGIRR/TIR‐8 is an inhibitor of toll‐like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

Abstract

Our study is the first to show the expression pattern and function of SIGIRR in primary human cells. Furthermore, this investigation defines the role of SIGIRR in disease-relevant cell types and demonstrates that SIGIRR is a potential therapeutic target for RA.