Chemistry - A European Journal · 2012 · 367 citations · 89 references
Natural SciencesChemistryMedicinal ChemistryNatural Product BiosynthesisOrganic ChemistryReaction EngineeringCross-coupling ReactionsNatural Product Drug DiscoveryOrganic SynthesisReaction MechanismsLate-stage Functionalization Via Cross-couplingNatural Product FunctionalizationNatural Product SynthesisQuinone ChemistryQuinone MethidesReactivity
ortho-Quinone methides (o-QMs) are emerging as highly useful intermediates, the inherent reactivity of which can be used in linchpin reactions for the construction of complex natural products. This review encompasses the major contributions in this field, exemplifying the major strategies and reactivity modes which can be applied.
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