Peripheral Formalin Injection Induces Long-Lasting Increases in Cyclooxygenase 1 Expression by Microglia in the Spinal Cord

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

David Dubuisson, Stephen G. Dennis · Pain · 1977 · 2.5K citations

Medicine, Neuroscience, Pharmacology +17

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

Naduviladath Vishvanath Chandrasekharan, Hu Dai, Katarina Roos et al. · Proceedings of the National Academy of Sciences · 2002 · 2K citations · Full text

Medicine, Biochemistry, Pharmacology +13

Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

Tarek A. Samad, Kimberly A. Moore, Adam Sapirstein et al. · Nature · 2001 · 1.3K citations

Life Sciences, Immunology, Neurobiology +14

Up‐regulation of cyclooxygenase‐2 mRNA in the rat spinal cord following peripheral inflammation

Flora Beiche, Stefan Scheuerer, Kay Brune et al. · FEBS Letters · 1996 · 329 citations · Full text

Life Sciences, Pharmacology, Gene Expression +14

Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats

AB Malmberg, TL Yaksh · Journal of Neuroscience · 1995 · 302 citations · Full text

Medicine, Pharmacology, Neuropharmacology +13