A Near Haploid Clone: 24, XY, t (9; 22) (q34; q11) from a Patient in Blast Crisis of Chronic Myeloid Leukaemia

Abstract

Chromosome studies on bone marrow in a patient with chronic myeloid leukaemia (CML) revealed a mosaic picture with a dominant clone of 24,XY, t(9; 22) (q34; q11). This corresponded to a preponderance of minute blasts in smears of bone marrow aspirate. It is suggested that a haploidy event rather than progressive hypodiploid loss, is responsible for the genesis of the miniature blast cells.