Synergistic Effect of Graphene and Multiwalled Carbon Nanotubes on a Glassy Carbon Electrode for Simultaneous Determination of Uric Acid and Dopamine in the Presence of Ascorbic Acid

Abstract

A poly(diallyldimethylammonium chloride)-graphene-multiwalled carbon nanotube modified glassy carbon electrode was fabricated and evaluated by cyclic voltammetry and differential pulse voltammetry. The modified electrode offered high sensitivity, selectivity, excellent long-term stability, and electrocatalytic activity for uric acid and dopamine. This sensor showed wide linear dynamic ranges of 5.0 to 350.0 µmol L−1 for uric acid and 10.0 to 400.0 µmol L−1 for dopamine in the presence of 500 µmol L−1 ascorbic acid. The limits of detection were 0.13 for uric acid and 0.55 µmol L−1 for dopamine. This functionalized electrode has potential application in bioanalysis and biomedicine.