Concepedia

A Comparison of Once-Daily Extended-Release Methylphenidate Formulations in Children With Attention-Deficit/Hyperactivity Disorder in the Laboratory School (The Comacs Study)

James M. Swanson, Sharon B. Wigal, Tim Wigal, Edmund Sonuga‐Barke, Laurence L. Greenhill, Joseph Biederman, Scott H. Kollins, Annamarie Stehli Nguyen, Heleen H. DeCory, Sharon J. Hirshe Dirksen,

PEDIATRICS · 2004 · 238 citations · 25 references

DOI

Abstract

Once-daily doses of MCD and CON produced statistically significantly different PD effects on surrogate measures of behavior and performance among children with attention-deficit/hyperactivity disorder in the laboratory school setting. As predicted by the PK/PD model, superiority at any point in time was achieved by the formulation with the highest expected plasma MPH concentration.

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