Journal of Asthma · 1998 · 101 citations · 6 references
PharmacyPharmacologyInflammationPulmonary Function TestingRespiratory PharmacotherapyAsthma ManagementAsthma PharmacotherapyBronchodilator TherapyForced Expiratory VolumeAirway Inflammation CorrelatesAsthmatic Airway InflammationExhaled Nitric OxideForced Vital Capacity ChangeInhaled Corticosteroid EffectsInhaled Nitric Oxide TherapyInhaled TherapiesNitric Oxide
The measurement of exhaled nitric oxide (ENO) is recognized as a marker of airway inflammation. ENO was measured in 10 nonsteroid-treated asthmatics at recruitment, during 3 weeks of inhaled beclomethasone (1000 microg/day) and for 3 weeks after withdrawal. Baseline ENO was increased in asthma compared with nonasthmatics (85.0+/-54.5 vs. 24.5+/-14.8 ppb, p < 0.0001). After inhaled steroid, there was no significant change in forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC), but methacholine PC20 rose significantly (p = 0.0345). ENO (mean+/-SD; % baseline) fell after 1 week on steroid to 60.6+/-31.1 and rose to 95.3+/-46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r2 = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma.
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Increased nitric oxide in exhaled air of asthmatic patients
Sergei A. Kharitonov, D. H. Yates, R A Robbins et al. · The Lancet · 1994 · 1.4K citations
Medicine, Internal Medicine, Allergy +14
Single-breath nitric oxide measurements in asthmatic patients and smokers
Magnus G. Persson, L.E. Gustafsson, O. Zetterström et al. · The Lancet · 1994 · 489 citations