Convenient Synthesis of <i>N</i>-Hydroxysuccinimide Esters from Carboxylic Acids Using Triphosgene

Abstract

Abstract A simple and convenient method for the synthesis of N-hydroxysuccinimide ester is developed using triphosgene as an acid activator. Several aromatic and aliphatic N-hydroxysuccinimide esters are prepared from their corresponding carboxylic acids at room temperature in good yields in a rapid process using triphosgene. Some of the major advantages are mild conditions, good yields, and easy operation.