Journal of the Chemical Society Perkin Transactions 2 · 2001 · 57 citations · 4 references
Natural SciencesBiochemistryBiophysicsLipid BiochemistryMagnetic Resonance BiophysicsMolecular ImagingContrast AgentsContrast MediaMagnetic Resonance Contrast MechanismsMagnetic Resonance ImagingMagnetic Resonance Imaging PhysicsMagnetic Resonance Molecular ImagingContrast Agent DesignIn-vitro CharacterizationLipid Imaging ProbesMagnetic Resonance Imaging Contrast AgentsMolecular Contrast AgentsPh DependenceResponsive Contrast AgentsResponsive Mri Probes
A series of Gd-DO3A derivatives (8a–d) mimicking phospholipids have been prepared. Two of the complexes, Gd-HADB-DO3A (8a) and Gd-HADO-DO3A (8b), have been evaluated as pH responsive MRI contrast agents in vitro. The T1-relaxivity (r1) of Gd-HADO-DO3A (8b) increased 142% on changing the pH from 6 to 8. The pH dependence is thought to arise from the formation of supramolecular structures caused by deprotonation of the amphiphilic complex at alkaline pH.
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Synthesis of Lipophilic Paramagnetic Contrast Agents
William C. Baker, Michael Choi, Daniel C. Hill et al. · The Journal of Organic Chemistry · 1999 · 46 citations