Synthesis and in vitro antibacterial activity of fluoroquinolone derivatives containing 3-(N′-alkoxycarbamimidoyl)-4-(alkoxyimino) pyrrolidines

Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

Hiroshi Koga, Akira Itoh, Satoshi Murayama et al. · Journal of Medicinal Chemistry · 1980 · 483 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli

Daniel J. Dwyer, Michael A. Kohanski, Boris Hayete et al. · Molecular Systems Biology · 2007 · 467 citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Novel Fluoroquinolone Antibacterial Agents Containing Oxime-Substituted (Aminomethyl)pyrrolidines:  Synthesis and Antibacterial Activity of 7-(4-(Aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro- 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic Acid (LB20304)^,1

Chang Yong Hong, Young Kwan Kim, Jay Hyok Chang et al. · Journal of Medicinal Chemistry · 1997 · 127 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14

Studies on 6-Aminoquinolones:  Synthesis and Antibacterial Evaluation of 6-Amino-8-methylquinolones

Violetta Cecchetti, Arnaldo Fravolini, Maria Cristina Lorenzini et al. · Journal of Medicinal Chemistry · 1996 · 65 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Synthesis and in vitro antibacterial activity of 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl)fluoroquinolone derivatives

Yun Chai, Zhi‐Long Wan, Bo Wang et al. · European Journal of Medicinal Chemistry · 2009 · 47 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12