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A liquid chromatography/electrospray ionization mass spectrometry (LC–MS/MS) assay for the determination of irinotecan (CPT-11) and its two major metabolites in human liver microsomal incubations and human plasma samples

BiochemistryMedicineBioanalysisMass SpectrometryHuman Plasma SamplesMetabolomic ProfilingAnalytical ChemistryHepatotoxicityMajor MetabolitesLiquid ChromatographyClinical ChemistryMetabolomicsPharmacologyHuman MetabolismPharmacokineticsChromatographyDrug Analysis