Optics Letters · 2009 · 42 citations · 11 references
MedicineBiomedical EngineeringSurgeryBiomedical OpticsBiophotonicsMicrosurgeryConfocal MicroscopyEndoscopic InstrumentsEndoscopic SurgeryLaser SurgeryMicrosurgical InstrumentationMicrosurgical InstrumentsConfocal Fluorescence MicroscopyEndoscopic Microsurgical InstrumentsEndoscopic Optical ImagingFiber-optic EndoscopesFiber-optic EndoscopyFiber-optic ProbesMicro ProbesTwo-dimensional Imaging
We demonstrate an endoscope-compatible single-fiber-based device that performs simultaneous confocal microscopy and high-precision laser microsurgery. The method is based on mapping of two-dimensional sample coordinates onto the optical spectrum and allows us to perform two-dimensional imaging and microsurgery without any mechanical movement of the probe or the sample. The technology holds promise for creating highly miniaturized endoscopes for applications such as brain tumor, pediatric, and endovascular surgeries where high-precision, small, and flexible probes are required.
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High-speed, miniaturized fluorescence microscopy in freely moving mice
Benjamin A. Flusberg, Axel Nimmerjahn, Eric D. Cocker et al. · Nature Methods · 2008 · 395 citations