Applied Physics A · 2010 · 76 citations · 25 references
EngineeringBioengineeringNeuroscienceElectrophysiologyNeural EngineeringNeurophysiologyAction PotentialsNeural CircuitsNeural Recording TechnologiesNeural Signal AcquisitionNeural Signal ProcessingSpiking Neural NetworksCorrelationElectrophysiology Of Nervous SystemsHigh-density Neural RecordingNeural RecordingNeural Recording SystemsNeuronal ElectrophysiologyReadoutSampling
The electrical activity of a network of mammalian neurons is mapped with a Multi-Transistor Array (MTA) fabricated with extended CMOS technology. The spatial resolution is 7.4 μm on an area of 1 mm 2 at a sampling frequency of 6 kHz for a complete readout of 16,384 sensor transistors. Action potentials give rise to extracellular voltages with amplitudes in a range of 500 μV. On the basis of the high resolution in space and time, correlation algorithms are used to identify single action potentials with amplitudes as low as about 200μV, and to assign the signals to the activity of individual neurons even in a dense network.
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