5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

Characterization of a novel aquaretic agent, OPC‐31260, as an orally effective, nonpeptide vasopressin V₂ receptor antagonist

Yoshitaka Yamamura, Hidenori Ogawa, Hiroshi Yamashita et al. · British Journal of Pharmacology · 1992 · 347 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Potent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men.

Akihiro Ohnishi, Y Orita, Ryunosuke Okahara et al. · Journal of Clinical Investigation · 1993 · 155 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

5-Fluoro-2-methyl-<i>N</i>-[4-(5<i>H</i>-pyrrolo[2,1-<i>c</i>]- [1,4]benzodiazepin-10(11<i>H</i>)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist with Selectivity for V₂Receptors

J. Donald Albright, Marvin F. Reich, Efren G. Delos Santos et al. · Journal of Medicinal Chemistry · 1998 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Orally Active, Nonpeptide Vasopressin V₂ Receptor Antagonists:  A Novel Series of 1-[4-(Benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1<i>H</i>-benzazepines and Related Compounds

Hidenori Ogawa, Hiroshi Yamashita, Kazumi Kondo et al. · Journal of Medicinal Chemistry · 1996 · 87 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Recent Advances in the Discovery and Development of Vasopressin Antagonists: Peptide and Nonpeptide Vta and V2 Receptor Antagonists

J. Donald Albright, Peter S. Chan · Current Pharmaceutical Design · 1997 · 30 citations

Medicine, Pharmacology, Pharmacotherapy +17