Proceedings of the National Academy of Sciences · 1996 · 191 citations · 34 references
Life SciencesNeurobiologyNeuroscienceNeuroanatomyNeurophysiologySensory NeuroscienceCentral Nervous SystemGabaergic SignalingInferior Colliculus AnatomyNeurotransmissionSynaptic TransmissionVisual SystemBrain NucleiInferior Colliculus Afferent PathwaysInferior Colliculus Neuroanatomical ConnectivityInferior Colliculus Projections To The ThalamusInhibitory NeurotransmissionMedial Geniculate BodyMedial Geniculate NucleusThalamus Nuclei
Comparable GABAergic input to visual or somesthetic thalamic nuclei is absent, highlighting a unique feature of the auditory system. The GABAergic projection ascends directly from the inferior colliculus to the MGB alongside the classical pathway, potentially providing inhibitory input. In cats, a robust bilateral GABAergic projection from the inferior colliculus to the MGB accounts for 10–30 % of auditory tectothalamic neurons, indicating prominent monosynaptic inhibition that distinguishes the auditory thalamus from visual and somesthetic counterparts.
A novel and robust projection from gamma-aminobutyric acid-containing (GABAergic) inferior colliculus neurons to the media] geniculate body (MGB) was discovered in the cat using axoplasmic transport methods combined with immunocytochemistry. This input travels with the classical inferior colliculus projection to the MGB, and it is a direct ascending GABAergic pathway to the sensory thalamus that may be inhibitory. This bilateral projection constitutes 10-30% of the neurons in the auditory tectothalamic system. Studies by others have shown that comparable input to the corresponding thalamic visual or somesthetic nuclei is absent. This suggests that monosynaptic inhibition or disinhibition is a prominent feature in the MGB and that differences in neural circuitry distinguish it from its thalamic visual and somesthetic counterparts.
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THE NEURONAL ARCHITECTURE OF THE MEDIAL GENICULATE BODY OF THE CAT.
D.K. Morest · PubMed · 1964 · 334 citations