Molecules · 2013 · 26 citations · 22 references
Molecular PharmacologyMedicinal ChemistryCocl2-induced NeurotoxicityBiochemistryMedicineNatural SciencesPharmacological AgentNeuropharmacologyDifferentiated Pc12 CellsNeuroprotectionPromising Protective EffectPharmacologyProtective EffectPharmaceutical ChemistryDrug DiscoveryOxidative Stress
A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC50 = 4.249 µM). Structure-activity relationships are briefly discussed.
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Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo
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Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents
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