Natural product letters · 1994 · 14 citations · 7 references
MedicineMedicinal ChemistryPharmacologyDrug DiscoveryNeuropharmacologyStructure-activity RelationshipsGabaergic NeurochemistryGabaergic PharmacologyGabaergic SignalingIon Channel PharmacologyReceptor PharmacologyStructure-activity Relationship AnalysisChloride Channel PharmacologyDrug Binding To Ion ChannelsGaba AntagonistsGaba-a Receptor PharmacologyGaba-gated Chloride Channel AntagonismGabaergic Drug Discovery
Abstract Bioassay-guided fractionation of the ethyl acetate extracts of the culture filtrate of the fungal culture HA 137–89 yielded the two salicylic acid derivatives 1 and 2, as inhibitors of the binding of 35S-TBPS to the GABAA/benzodiazepine chloride channel receptor complex in vitro. Their structures were determined by spectroscopic and chemical methods.
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Three triterpenes and other terpenoids from Catha cassinoides
Carmen Betancor, Raimundo Freire, Antonio González et al. · Phytochemistry · 1980 · 74 citations
New triterpene dimers from maytenus ilicifolia
Hideji Itokawa, Osamu Shirota, Hiroshi Morita et al. · Tetrahedron Letters · 1990 · 36 citations